2013•Chinese journal of integrated traditional and Western medicineRequires access
The Research of Niweikang in protecting gastric mucosa of rats with chronic atrophic gastritis
Zhou Guang-x
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Abstract
[Objective]To investigate Niwekang in protecting gastric mucosa of rats with chronic atrophic gastritis(CAG).[Methods]Sixty healthy male Wistar rats were randomly assigned into normal control group(n=10),CAG model group(n=10),Niweikang intervention group(n=30)and teprenone intervention group(n=10).Rats in CAG model group were administered intragastrically with Helicobacter pylori suspension and alcohol-sodium salicylate solution sequentially to construct CAG model for 14weeks.Rats in Niweikang intervention group and teprenone intervention group were given additional Niweikang and teprenone for 14weeks,respectively.Rats in normal control group were treated with normal saline with the same volume as the model group for 14weeks.Gross pathological and histopathological changes in gastric mucosa was observed,and the content of gastric hexosamine in 4groups were detected,using the method of ELISA.The content of NO,SOD and Bcl2in serum of 4groups were detected[Results]The content of NO,SOD and hexosamine in Niweikang intervention group,teprenone intervention group and normal control group was higher than those in CAG model group,and the differences were statistically significant(P0.05);the content of Bcl2in these three groups were lower than that in CAG model group,and the difference was statistically significant(P0.05).However,the differences of SOD,NO,Bcl2and hexosamine between Niweikang intervention group and teprenone intervention group had no statistical difference(P0.05).[Conclusion]Niweikang has a similar protective effect to teprenone on gastric mucosa of rats,and the mechanisms may be related to the up regulation of NO,SOD,hexosamine and down regulation of Bcl2.