Clinical Value of D-dimer Detection in Diagnosing and Monitoring of Ovarian Cancer

OBJECTIVE:To study the application and clinical significance of D-dimer detection in diagnosing and monitoring of ovarian cancer.METHODS: The D-dimer concentration in 45 cases of ovarian cancer and 34 cases of benign ovarian tumor and 42 healthy women(control) were detected by immunoturbidimetric assay.RESULTS: The plasma D-dimer level in ovarian cancer group was significant higher than in ovarian benign tumor group and control group(P0.01),while there were no statistic differences between benign tumor group and control group(P0.05).The D-dimer levels were not significantly different among ovarian cancer patients of different pathological types(P0.05) or among benign ovarian tumor patients of different pathological type(P0.05);however,the D-dimer level in the ovarian cancer patients of stage Ⅱ-Ⅳ was significant higher than in those of stageⅠ(P0.01).The D-dimer level in ovarian cancer patients of different pathological grade increased from G1 to G3 grade in order and the differences were statistically significant(P0.01).CONCLUSION: The detection of D-dimer has very important clinical value for the differential diagnosis of ovarian cancer and the progression and staging evaluation of cancer.D-dimer plays a special role in the laboratory diagnosis of ovarian cancer.