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2005•Journal of Zhengzhou UniversityRequires access

Expression of TRAIL and its receptors in astrocytoma tissue

Zhifeng Zhang

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Abstract

Aim: To study the expression and role of TRAIL and its receptors in astrocytoma tissue of different grades. Methods: The mRNA of TRAIL and its receptors DR4,DR5,DcR1,and DcR2 in 45 specimens of surgically resected astrocytoma and 8 specimens of normal brain tissue were detected by in situ hybridization. Results: Of 45 cases of astrocytoma, the expression of TRAIL mRNA,DR4 mRNA,DR5 mRNA,DcR1 mRNA, and DcR2 mRNA was found in 44 cases,38 cases,41 cases, 40 cases, and 2 cases, respectively.The co-transcription of DR4 mRNA,DR5 mRNA and DcR1 mRNA was detected in 36 cases of astrocytoma, and the positive expression rate was 80%.There was no significant difference in expression of TRAIL and its receptors between low-grade and high-grade astrocytoma tissue. Conclusion: The expression of TRAIL and its receptors is found in astrocytoma tissue,which is not correlated with the malignant degree of astrocytoma.

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Aim: To study the expression and role of TRAIL and its receptors in astrocytoma tissue of different grades. Methods: The mRNA of TRAIL and its receptors DR4,DR5,DcR1,and DcR2 in 45 specimens of surgically resected astrocytoma and 8 specimens of normal brain tissue were detected by in situ hybridization. Results: Of 45 cases of astrocytoma, the expression of TRAIL mRNA,DR4 mRNA,DR5 mRNA,DcR1 mRNA, and DcR2 mRNA was found in 44 cases,38 cases,41 cases, 40 cases, and 2 cases, respectively.The co-transcription of DR4 mRNA,DR5 mRNA and DcR1 mRNA was detected in 36 cases of astrocytoma, and the positive expression rate was 80%.There was no significant difference in expression of TRAIL and its receptors between low-grade and high-grade astrocytoma tissue. Conclusion: The expression of TRAIL and its receptors is found in astrocytoma tissue,which is not correlated with the malignant degree of astrocytoma.

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Available abstract

Aim: To study the expression and role of TRAIL and its receptors in astrocytoma tissue of different grades. Methods: The mRNA of TRAIL and its receptors DR4,DR5,DcR1,and DcR2 in 45 specimens of surgically resected astrocytoma and 8 specimens of normal brain tissue were detected by in situ hybridization. Results: Of 45 cases of astrocytoma, the expression of TRAIL mRNA,DR4 mRNA,DR5 mRNA,DcR1 mRNA, and DcR2 mRNA was found in 44 cases,38 cases,41 cases, 40 cases, and 2 cases, respectively.The co-transcription of DR4 mRNA,DR5 mRNA and DcR1 mRNA was detected in 36 cases of astrocytoma, and the positive expression rate was 80%.There was no significant difference in expression of TRAIL and its receptors between low-grade and high-grade astrocytoma tissue. Conclusion: The expression of TRAIL and its receptors is found in astrocytoma tissue,which is not correlated with the malignant degree of astrocytoma.

Key concepts: Astrocytoma, Messenger RNA, Receptor, In situ hybridization, Brain tissue, Pathology, Immunohistochemistry, Biology

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