2005•Chinese Journal of Clinical Oncology and RehabilitationRequires access
Expression of DR4 and DR5 in human anaplastic astrocytoma
Zhao Zhong-wei
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Abstract
Objective To investigate the expression and significance of DR4 and DR5 in human anaplastic astrocytoma.Methods The expression of DR4 and DR5 was determined by immunohistochemistry and in situ hybridization in 24 samples of anaplastic astrocytoma and 16 samples of normal brain tissue.Results DR was expressed highly in all anaplastic astrocytoma samples,while its expression in part of normal brain tissue was low.DR protein expression in anaplastic astrocytoma tissue was significantly higher than that in normal brain tissue(P(0.01)).There was no significant difference between the expression of DR mRNA in normal brain tissue and that in anaplastic astrocytoma tissue(P0.05).Conclusions High DR expression is prevalent in anaplastic astrocytoma tissue and this may contribute to the apoptosis-inducing therapy of anaplastic astrocytoma.The difference in expression of DR protein in normal brain tissue and in anaplastic astrocytoma may be one of the mechamisms of selective induction of apoptosis by TRAIL.