2007•Zhongguo linchuang yaolixue yu zhiliaoxueRequires access
Effect of matrine on U937 cells and human umbilical vein endothelial cells proliferation
Zong-Gan Huang
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Abstract
AIM:To observe the proliferative effects of matrine on U937 cells and human umbilical vein endothelial cells. METHODS: The effects of matrine on U937 cells and human umbilical vein endothelial cells proliferation were observed by morphology, MTT and cell cycle detection. RESULTS: U937 cells treated with matrine at the concentration of 0.2 mg/mL to 0.5 mg/mL for 24 h were inhibited proliferation in a time and dose-dependent manner detected by MTT (P0.05 or P0.01) and increased at the S stage (P0.05 or P0.01). The half-inhibition concentration (IC50) was 0.4 mg/mL in U937 cells compared with human umbilical vein endothelial cells (P0.05). HUVECs treated with matrine at the concentration of 0.1 to 0.5 mg/mL for 48 h showed no effect on cell cycle (P0.05). CONCLUSION: Matrine has an inhibited effect on U937 cells proliferation in a time and dose-dependent manner.