Clinical study on plasma HS-CRP and LPα and APN of patients with coronary slow flow on intensive atorvastatin treatment

Objective: To investigate the effects of intensive atorvastatin treatment on coronary slow flow patients. Whether it could change the levels of plasma C-reactive protein and lipoprotein α and APN in patients with CSF after 3month therapy. Methods:All of the patients were informed and consented, 98 patients of CSF were diagnosed with coronary angiography and were randomly divided into moderate group(49 patients) and intensive group(49 patients). The moderate group were given atorvastatin 20 mg 1/d and the intensive group were given atorvastatin 40 mg 1/d. The plasma C-reactive protein(hs-CRP) and lipoprotein α(LPα)and APN levels were tested in the two groups before and after three months. Results: There was significant difference between two groups. The plasma hs-CRP and LPα of patients were significantly decreased in intensive group compared with moderate group[hs-CRP(2.24±1.2) mg/L vs(1.46±1.0) mg/L,LPα(242±39.8) mg/L vs(191±28.3) mg/L,P0.05];The APN levels of patients were significantly increased in intensive group compared with moderate group[APN(4.2 ±1.3) mg/L vs(4.8 ±1.4) mg/L,P 0.05] after 3 month therapy. Conclusion: Intensive statin therapy could decrease plasma LPα and hs-CRP levels and increase APN level significantly in coronary slow flow patients.