Effects of atorvastatin with different doses on hs-CRP level in patients with acute coronary syndrome

Objective:To investigate effects of atorvastatin with different doses on levels of blood lipid and serum high sensitive C-reactive protein(hs-CRP) in patients with acute coronary syndrome(ACS).Methods:A total of 128 ACS patients were randomly divided into large dosage of atorvastatin group(40mg/d,n=64) and routine dosage of atorvastatin group(20mg/d,n=64).Serum levels of blood lipid,hs-CRP of the two groups were measured with biochemistry assay within 24h after admission,3d and 7d after therapy.The difference in blood lipid and hs-CRP levels was compared between the two groups.Results:(1)After 7d,levels of total cholesterol(TC)[routine dosage group:(4.4±0.9) mmol/L vs.(5.6±1.2) mmol/L,large dosage group:(4.2±0.9) mmol/L vs.(5.7±1.2) mmol/L]and low density lipoprotein-cholesterol(LDL-C) [routine dosage group:(2.1±0.6) mmol/L vs.(3.3±0.7) mmol/L,large dosage group:(2.3±0.7) mmol/L vs.(3.4±0.8) mmol/L]significantly decreased compared with before treatment(P0.05 all),but there was no significant difference between the two groups for above indexes before and after treatment(P0.05);(2)After 7d,hs-CRP level of large dosage group significantly decreased compared with before treatment [(5.0±1.9)mg/L vs.(17.5±6.4)mg/L],and it was more than that of routine dosage group [(7.1±4.8) mg/L,P0.01 all].Conclusion:Application of large dosage of atorvastatin could better decrease hs-CRP level in patients with acute coronary syndromes.