2005•Unpublished venueRequires access

Effect of Oxymartrine on Malondialdehyde Concentration and Superoxide Dismutase Activity in the Brain Tissue of Epileptic Rat

Jie Bai

Abstract

Objective To study the effect of Oxymartrine (OMT) on the concentration of malondialdehyde (MDA) and the enzyme activity of superoxide dismutase (SOD) in the brain tissue of epileptic rats. Methods The epileptic animal model was induced by administration of Penicillin then OMT was given (i.p) to each animal. The concentration of MDA and the activity of SOD were examined, respectively. Results MDA concentration was elevated in epileptic rats. Administration of OMT decreased the MDA levels and increased the SOD activity in the brain tissue of epileptic rats. Conclusion The study suggested that peripherally administered OMT may scavenge free radicals in the brain tissue of iron-induced epileptic animals.

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Key concepts: Malondialdehyde, Superoxide dismutase, Brain tissue, Chemistry, Penicillin, Epilepsy, Pharmacology, Epileptic seizure