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2003•Zhejiang Medical JournalRequires access

The effect of Melatonin on malondialdehyde concentration and superoxide dismutase activity in the brain tissue of epileptic rat

Pan Yizhen

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Abstract

Objective To study the effect of Melatonin(MT)on the concentration of malondialdehyde(MDA)and the enzyme activity of superoxide dismutase(SOD)in the brain tissue of epileptic rats.Methods The epileptic animal model was induced by intracortical injection of FeCl 3 in rats and0.3mmol/kg of MTwas given(i.p)to each animals.The concentration of MDA was measured with thiobarbituric acid method and the activity of SOD was examined with xanthine oxidase method.Results MDA concentration was elevated in epileptic rats.Administration of0.3mmol/kg MTdecreased the MDA levels and increased the SOD activity in the brain tissue of epileptic animals.Conclusion The study suggests that peripherally administered MT may scavenge free radicals in the brain tissue of iron-induced epileptic animals.

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Objective To study the effect of Melatonin(MT)on the concentration of malondialdehyde(MDA)and the enzyme activity of superoxide dismutase(SOD)in the brain tissue of epileptic rats.Methods The epileptic animal model was induced by intracortical injection of FeCl 3 in rats and0.3mmol/kg of MTwas given(i.p)to each animals.The concentration of MDA was measured with thiobarbituric acid method and the activity of SOD was examined with xanthine oxidase method.Results MDA concentration was elevated in epileptic rats.Administration of0.3mmol/kg MTdecreased the MDA levels and increased the SOD activity in the brain tissue of epileptic animals.Conclusion The study suggests that peripherally administered MT may scavenge free radicals in the brain tissue of iron-induced epileptic animals.

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Available abstract

Objective To study the effect of Melatonin(MT)on the concentration of malondialdehyde(MDA)and the enzyme activity of superoxide dismutase(SOD)in the brain tissue of epileptic rats.Methods The epileptic animal model was induced by intracortical injection of FeCl 3 in rats and0.3mmol/kg of MTwas given(i.p)to each animals.The concentration of MDA was measured with thiobarbituric acid method and the activity of SOD was examined with xanthine oxidase method.Results MDA concentration was elevated in epileptic rats.Administration of0.3mmol/kg MTdecreased the MDA levels and increased the SOD activity in the brain tissue of epileptic animals.Conclusion The study suggests that peripherally administered MT may scavenge free radicals in the brain tissue of iron-induced epileptic animals.

Key concepts: Malondialdehyde, Superoxide dismutase, Thiobarbituric acid, Melatonin, Xanthine oxidase, Brain tissue, Medicine, Pharmacology

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