Influence of Shugan Hewei Decoction on Periphery Esophageal Visceral Sensitivity in Non-erosive Gastroesophageal Reflux Disease Model Rats

Objective:To observe the effect and mechnism of Shugan Hewei Decoction on periphery esophageal visceral sensitivity in the non-erosive gastroesophageal reflux disease(NERD)model rats.Methods:Totally 60 Sprague-Dawley rats were randomized into a blank control group(normal group),model group,Omeprazole Sodium group,Shugan Hewei Decoction group.Except for the normal group,the rats of all the other groups received basal ovalbumin-sensitization combined with intra-esophageal mucosal acid exposure for making NERD models.Then,the treatment was given for 14 days.The comparative observation was carried out on the changes of uhrastruetural characteristics and the expression of substance P(SP)and caltenin gene related peptide(CGRP)in esophagueal mucosa from SD rats.Results:Compared with the model group,the Omeprazole Sodium group and Shugan Hewei Decoction group also reduced the expressions of SP and CGRP in esophagueal mucosa from NERD model rats(P0.05).Transmission electron microscope showed nucleolus clearness and coloretur well-distributed and interstitial space dilation well-distributed in esophagueal mucosa.Conclusion:Shugan Hewei Decoction plays a role in inhibiting esophageal visceral sensitivity by the way of improving the changes of uhrastruetural characteristics and down-regulating the expressions of SP and CGRP in esophagueal mucosa from rats.