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Study on NO/NOS Content of Serum and Brain Tissue in Cerebral Ischemia-reperfusion Injury Rats

Shunwu Xiao

Abstract

Objective To discuss the effect of nitric oxide(nitric oxide,NO) and nitric oxide synthase(nitric oxidesynthetase,NOS) in cerebral ischemia-reperfusion injury.Methods Focal cerebral ischemia was induced by 60min of middle cerebral artery occlusion and followed by 3d reperfusion,after cerebral ischemia-reperfusion injury rats model was established,NO/NOS concentration change of serum and brain tissue was determinated by absorption spectrometry.Results NO/NOS content in cerebral ischemia-reperfusion injury rats was significantly higher than control group(P0.05).Conclusion NO/NOS may play an important role in cerebral ischemia-reperfusion injury.

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Key concepts: Medicine, Nitric oxide, Ischemia, Reperfusion injury, Nitric oxide synthase, Anesthesia, Brain tissue, Internal medicine