Clinical study on the left ventricular diastolic function of hypertrophy by real-time three-dimensional echocardiography and quanti-tative tissue velocity imaging

Objective:To assess the feasibility and accuracy of real-time three-dimensional echocardiography (RT-3DE) and quantitative tissue velocity imaging(QTVI) in quantifying left ventricular diastolic function.Methods:Twenty healthy volunteers without cardiovascular diseases and twenty patients with left ventricular hypertrophy were investigated,and the quantitative analyses were blinded to each other.To measure the left ventricular mass (LVM) ,peak filling rate (PFR) of them by realtime three-dimensional echocardiography (RT-3DE).To measure tissue move ahead duration midpt (TMAD Midpt),peak myocardial sustained early diastolic velocity (Ve),peak myocardial sustained late diastolic velocity (Va) of them by quantitative tissue velocity imaging (QTVI).Results:Clear endocardial border,real-time three-dimensional and two-dimensional images were obtained in all 40 cases.There were significant differences of left ventricular mass (LVM),left ventricular mass index (LVMI),filling rate (PFR)between the two groups ( P 0.01).Mitral annulus maximum displacement (TMAD Midpt) also showed significant differences between the measured values ( P 0.01).Septal,lateral basal segment of left ventricular early diastolic and late diastolic peak velocity (Ve,Va) and the ratio (Ve / Va) showed significant difference between measured values ( P 0.01).Left ventricular filling rate (PFR) ,left ventricular septal and lateral basal diastolic peak early and late diastolic velocity ratio (Ve / Va) ,the largest mid-point of mitral annular displacement (TMAD Midpt) had a high correlation with the early diastolic and late diastolic velocity ratio (E/A) on traditional two-dimensional echocardiography test,the correlation coefficients were 0.962,0.961,0.434.Conclusion;Diastolic function left ventricular in healthy adult and patients with left ventricular hypertrophy has heterogeneity.RT-3DE and QTVI provides a new method in assessing the left ventricular function.