2012•Lishizhen Medicine and Materia Medica ResearchRequires access

Protective Effects of Dahuangzhechongwan against Rat Hepatic Fibrosis Induced by Carbon Tetrachloride

SU Juan-ping

Abstract

ObjectiveTo explore the protective mechanism of Dahuangzhechongwan on hepatic fibrosis. MethodsRat fibrosis model was established by CCl4 compound factors.Transforming growth factor β1(TGFβ1),tissue inhibitor of metalloproteinase-1(TIMP-1) were detected in the serum among different groups. ResultsDahuangzhechongwan could reduce the serum levels of TGFβ1,TIMP-1,Hyaluronic Acid(HA),Laminin(LN),Procolagen Type Ⅲ(PCⅢ),Collagen TypeⅣ(CⅣ),glutamic-pyruvic transaminase(ALT) and glutamic-oxalacetic transaminase(AST),respectively. ConclusionDahuangzhechongwan can inhibit the expression of TGFβ1 and TIMP-1,the two main factors were related to the occurrence of hepatic fibrosis.This may be one of the mechanisms which Dahuangzhechongwan restrains the progression of liver fibrosis.

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Key concepts: Carbon tetrachloride, Hepatic fibrosis, CCL4, Hyaluronic acid, Laminin, Fibrosis, Transaminase, Transforming growth factor