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Resistive Effects of Hongbeiyegen on Rat Hepatic Fibrosis Induced by Carbon Tetrachloride

Zhiping Lv

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Abstract

Objective:To explore the mechanism of Hongbeiyegen's resistive effects on hepatic fibrosis.Methods:Rat fibrosis models were established by CCl4 compound factors.Transforming growth factor β1(TGFβ1),tissue inhibitor of metalloproteinase-1(TIMP-1) were detected in the serum among the different groups.Results:Hongbeiyegen could reduce the serum level of TGFβ1,TIMP-1,Hyaluronic Acid(HA),Laminin(LN),Procolagen Type Ⅲ(PCⅢ),Collagen TypeⅣ(CⅣ),glutamic-pyruvic transaminase(ALT) and glutamic-oxalacetic transaminase(AST) respectively.Conclusion:Hongbeiyegen can inhibit the expression of TGFβ1 and TIMP-1,the two main factors related to the occurrence of hepatic fibrosis.This may be one of the mechanisms which Hongbeiyegen restrains the progression of liver fibrosis.

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What this paper is about

Objective:To explore the mechanism of Hongbeiyegen's resistive effects on hepatic fibrosis.Methods:Rat fibrosis models were established by CCl4 compound factors.Transforming growth factor β1(TGFβ1),tissue inhibitor of metalloproteinase-1(TIMP-1) were detected in the serum among the different groups.Results:Hongbeiyegen could reduce the serum level of TGFβ1,TIMP-1,Hyaluronic Acid(HA),Laminin(LN),Procolagen Type Ⅲ(PCⅢ),Collagen TypeⅣ(CⅣ),glutamic-pyruvic transaminase(ALT) and glutamic-oxalacetic transaminase(AST) respectively.Conclusion:Hongbeiyegen can inhibit the expression of TGFβ1 and TIMP-1,the two main factors related to the occurrence of hepatic fibrosis.This may be one of the mechanisms which Hongbeiyegen restrains the progression of liver fibrosis.

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Available abstract

Objective:To explore the mechanism of Hongbeiyegen's resistive effects on hepatic fibrosis.Methods:Rat fibrosis models were established by CCl4 compound factors.Transforming growth factor β1(TGFβ1),tissue inhibitor of metalloproteinase-1(TIMP-1) were detected in the serum among the different groups.Results:Hongbeiyegen could reduce the serum level of TGFβ1,TIMP-1,Hyaluronic Acid(HA),Laminin(LN),Procolagen Type Ⅲ(PCⅢ),Collagen TypeⅣ(CⅣ),glutamic-pyruvic transaminase(ALT) and glutamic-oxalacetic transaminase(AST) respectively.Conclusion:Hongbeiyegen can inhibit the expression of TGFβ1 and TIMP-1,the two main factors related to the occurrence of hepatic fibrosis.This may be one of the mechanisms which Hongbeiyegen restrains the progression of liver fibrosis.

Key concepts: Medicine, Hepatic fibrosis, Carbon tetrachloride, Laminin, Hyaluronic acid, Transforming growth factor, Transaminase, CCL4

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