Application Study of Thinprep Liquid Based Cytology Test in the Detection of Cervical Diseases

Objective To assess the value of thinprep liquid based cytology test (TCT) and Besthesda system (TBS) in diagnosis of cervial lesions. Methods 11000 cases of cervical lesions were detected with TCT and TBS.The samples of atypical squamous cells(ASC) and more severe than ASC lesions were classified into postive cytology,and then cytological results were compared with pathological examination results of cervical biopsies.Results The satisfactory rate of TCT samples was 96.36%, and the postive rate of abnormal epithelial cells diagnosed by TCT was 10.96%(1206/11000). Among 1206 cases, 15 cases(0.14%) of CA, 89 cases (0.81%) of HSIL, 449 cases (4.08%) of LSIL, 73 cases (0.66%) of ASC-H and 580 cases (5.27%) of ASC-US and AGUS. 1128 cases with postive cytologic results received pathological examination. The pathological positive rate of CA, HSIL, LSIL, ASC-H, and ASC-US and AGUS were 100%, 100%, 67.12%, 54.17% and 14.09%, respectively. The coincident rate of two examination methods was 100% for CA, 91.1% for HSIL,57.82% for LSIL and 27.78% for ASC-H. Conclusion TCT and TBS can accurately detect cervical cancer, precancerous lesions and infection of bacteria, virus and other pathogens, and at present is a means of screening cervical cancer.