ANALYSIS OF THE EFFICIENCY OF DOWN'S SYDROME SCREENING LAB-SYSTEM

ObjectivesTo explore the efficiency of Down's Sydrome screening lab-system in our city.MethodsAFP,β-HCG in the serum of pregnant woman were measured using full-automatic Access Immunoassay Analysis system of Beckman Coulter,which were combined with relevant factors such as pregnant woman's age and gestational weeks to estimate the probability of fetus suffering from DS and ONTD.ResultsFrom 5 333 pregnant women,365 cases with high DS risk were sift out in preliminary screening,and the positive rate was 6.84%.There were 4 DS in the 365 pregnant women and 2 DS in 4 968 pregnant women without high DS risk in preliminary screening,the examination rate was 66.7%.In 5 333 pregnant women,196 cases with high ONTD risk were sift out in reliminary screening,and the positive rate was 3.68%.From 196 ONTD positive pregnant women,there were 13 abnormal pregnancy,which accounted for 6.33%,including 4 ONTD.From 5137 non-high ONTD risk pregnant woman,there were 5 abnormal pregnancy,accounting for 0.097%,in which there was no ONTD,and the ONTD examination rate was 100%.ConclusionsIn this system,the DS examination rate is 66.7%,in accord with the rate of 60%-70% reported by our country and Walds.The ONTD examination rate is 100%,better than 75%-90% reported by Thiagarjah S.It has fully proved that the DS screening system is reliable and effective.