Analysis on the maternal serum prenatal screening results of 1560 pregnant women during the second trimester of pregnancy

Objective To investigate the characteristics of prenatal screening results for Down's syndrome (DS), Edward's syndrome (ES) and open neural tube defects (ONTD), and to provide reference for clinical service. Methods Time-resolved fluoroimmunoassay was used to detect the count of uE3, free-β-hCG, AFP in serum of pregnant women during the second trimester. The software Lifecycle3.2 was used to calculate the risk values of DS, ES, ONTD by importing the data of uE3, free-β-hCG, AFP, age, body weight, et al. The pregrant women were followed up 2 months after postpartum for pregnancy outcome. Results The positive rate of the high risk DS was 5.32%. One case of the high risk DS was diagnosed definitely. The positive rate of high risk ES was 0.90%, and the positive rate of high risk ONTD was 0.64%. The positive rates of high risk DS of Hainan Provincial Maternity and Child Health Hospital and cooperation hospitals were different significantly ( χ 2 =4.72, P0.05). The positive rate of high risk DS cases of ≥35 year old was significantly higher than those for the patients of 35 year old (χ 2 =70.63, P 0.01), The positive rate of high risk DS cases of 35 year old was 3.71%. Conclusion Standardizing of the specimen collection and transportation are important for the prenatal screening in hospital cooperation. Pregnant women at any age should attach importance to prenatal screening.