Results of Prenatal Screenings with α-FTP and β-HCG in Mid-Term Pregnant Women From 2009 to 2012 in Yuhang District of Hangzhou

Objective To study and evaluate clinical application of prenatal screening with α-FTP and β-HCG in mid-term pregnant women from 2009 to 2012 in Yuhang district of Hangzhou. Methods The results of prenatal screening withα-FTP and β-HCG and chromosome analysis in 44 566 women in the third trimester of pregnancy from August,2008 to September,2012 in Yuhang Maternal and Child Health Hospital were analyzed respectively. Results Total 9 cases of DS,7 cases of trisomy 18 syndrome and 8 cases of open neural tube defects( ONTD) were diagnosed from high risky women; 6 cases of Down's syndrome and 6 cases of ONTD were diagnosed from low risky pregnant women. The follow up showed that the positive rate of prenatal screening in high risky women was 60. 00%( 9 /15),100. 00%( 7 /7) and 57. 14%( 8 /14) for DS,trisomy 18 syndrome and ONTD,respectively; The positive rate of Down's syndrome and other abnormal fetuses by chromosome analysis in the high risky women was higher than that in the low risky pregnant women,and difference between them was statistic significant( P 0. 001). Conclusion It was an effective indicator in decreasing the birth of abnormal fetuses to perform well the prenatal screening,but the explanation must be well carried out on the results being false positive or false negative.