Detection of serum hs-CRP and BNP in coronary heart disease patients with angina pectoris and its clinical significance

Objective To investigate the relationship between the serum levels of high-sensitivity C-reactive protein(hs-CRP) and brain natriuretic peptide(BNP) and the degree of illness and heart function in the coronary heart disease(CHD) patients positive for angina pectoris.Methods The survey group consisted of 115 angina patients whose CHD diagnosis was confirmed by positive CAG results,with 40 patients of negative CAG results taken to form the control group.In the angina patient survey group,there were 68 cases of stable angina(SA) and 47 cases of unstable angina(UA);35 patients with single-artery lesion,38 with two-artery lesion and 42 with three-artery lesion.The angina patients were also divided into groups according to the NYHA classification of heart failure.The serum levels of hs-CRP and BNP and the LVEF were measured;the data obtained were analyzed statistically.Results The serum levels of hs-CRP and BNP were significantly higher in the survey group than those in the control group(P0.05).These levels were significantly higher in UA group than in SA group (P0.05);significantly higher in the CHD patients with single-artery lesion than in the control(P0.05);significantly higher in CHD patients with two-artery or three-artery lesion than in those with single-artery lesion(P0.05);higher in the patients with three-artery lesion than in those with two-artery lesion(P0.05).The BNP level was positively correlated with the number of lesion vessels(r=0.65,P0.05),lesion score(r=0.301,P0.05) and NYHA classification of heart failure(r=0.78,P0.05).But the BNP level was negatively correlated to LVEF(r=-0.56,P0.05),and the hs-CRP and BNP levels increased with the degree of left ventricle dysfunction(P0.05).Conclusions Serum levels of hs-CRP and BNP can be used as assistant indexes for evaluating degree of CHD,classification of risk,and grade of heart function.