Detection of allergens in 165 children below 5 with wheeze and its clinical significance

Objective To explore the clinical significance of serum specific allergen test in early asthma diagnosis with wheezing children under 5 years old.Methods The seral total IgE,the specific IgE of 12 types of inhalation and food allergens were detected in 165 cases of children aged below 5 with asthma using the method of enzyme linked immunosorbent assay.The children were divided into infancy group(aged3) and 3-5 age group.Results In 165 cases,the positive ratio of total IgE was 89.1%.The positive ratio of specific allergens was 58.8%.The most common inhalation allergen was dust mite/acarid and the most common food allergen was egg white/yolk,followed by fish,shrimp/crab and meat.The number of inhalation allergens droped with the food of age,while the number of inhalation allergens rose.Conclusion Positive serum specific allergens is one of the highly hazardous factors which leads to childhood wheeze into asthma.Thus,the test of inhalation allergens and food allergens in serum for children with wheeze aged below 5 plays an important role in detecting the potential childrens with asthma early,and it provides the basis for early intervention in childhood asthma.