Effect of Different Does of Simvastatin in Reducing Serum Lipid

Objective:Comparing the effect of different doses of simvastatin in lowering the serum lipid. Methods:79 patients were randomized into group A and group B, and were given simvastatin 10 mg·d -1 (group A) and 20 mg·d -1 (group B), respectively for a total of 8 weeks. Results:Comparing with baseline, in group A, TC, TG, LDL-C were decreased by 23.4%, 20.0% and 30.7%, respectively (P0.01); HDL-C was increased by 17.5%. The content of serum TC, TG and LDL-C was decreased to the normal range in 12.8%, 28.2% and 15.4% of the patients in group A. For the group B, TC, TG, LDL-C were decreased by 32.7%, 22.8% and 42.8%, respectively (P0.01); HDL-C was increased by 13.7%. The content of serum TC, TG and LDL-C was decreased to the normal range in 65.0%, 57.5% and 65.0% of the group B patients. Conclusion:Oral intake of 20 mg of simvastatin once a day can effectively reduce the serum lipid. The patients can well tolerate and no obvious side effect was observed in our study.