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2001•Journal of Dali Medical CollegeRequires access

Comparision of the Lipid-regulating effect with Carious dose of simvastatin

Linhua Zhou

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Abstract

Objective: To compare the lipid-regulating effects of simvastatin with various dose in patients with hyperlipidemia.Methods: 43 patients with lipidemia were randomly divided into group A and group B, all were received 10mg/d and 20mg/d simvastatin resp-ectively.Serum lipid profile was determined before and 8 weeks after the treatment.Results: (1)After 8 weeks of treatment,serum total cholesterol (TC) and low density lipoprotein cholesterol(LDL-C) levels were decreased in two groups. (2)Serum triglyceride (TG) level was decreased and high density lipoprotein cholesterlo (HDL-C) level was increased in group B, both TG and HDL-C didn't change in group A(P0.05). (3) The lipoprotein (a)level decreased in both groups after 8 weeks of treatment. (4)In two groups,serum lipid profile were lowered in effective rate of 68.75％ and 90.32％ .Conclusion: 20mg/d simvastatin was more effective.

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What this paper is about

Objective: To compare the lipid-regulating effects of simvastatin with various dose in patients with hyperlipidemia.Methods: 43 patients with lipidemia were randomly divided into group A and group B, all were received 10mg/d and 20mg/d simvastatin resp-ectively.Serum lipid profile was determined before and 8 weeks after the treatment.Results: (1)After 8 weeks of treatment,serum total cholesterol (TC) and low density lipoprotein cholesterol(LDL-C) levels were decreased in two groups. (2)Serum triglyceride (TG) level was decreased and high density lipoprotein cholesterlo (HDL-C) level was increased in group B, both TG and HDL-C didn't change in group A(P0.05). (3) The lipoprotein (a)level decreased in both groups after 8 weeks of treatment. (4)In two groups,serum lipid profile were lowered in effective rate of 68.75％ and 90.32％ .Conclusion: 20mg/d simvastatin was more effective.

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Available abstract

Objective: To compare the lipid-regulating effects of simvastatin with various dose in patients with hyperlipidemia.Methods: 43 patients with lipidemia were randomly divided into group A and group B, all were received 10mg/d and 20mg/d simvastatin resp-ectively.Serum lipid profile was determined before and 8 weeks after the treatment.Results: (1)After 8 weeks of treatment,serum total cholesterol (TC) and low density lipoprotein cholesterol(LDL-C) levels were decreased in two groups. (2)Serum triglyceride (TG) level was decreased and high density lipoprotein cholesterlo (HDL-C) level was increased in group B, both TG and HDL-C didn't change in group A(P0.05). (3) The lipoprotein (a)level decreased in both groups after 8 weeks of treatment. (4)In two groups,serum lipid profile were lowered in effective rate of 68.75％ and 90.32％ .Conclusion: 20mg/d simvastatin was more effective.

Key concepts: Simvastatin, Medicine, Triglyceride, Hyperlipidemia, Internal medicine, Endocrinology, Lipid profile, Lipoprotein

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