Clinical Analysis of Simvastatin on the Advanced Aged Patients with Coronary Heart Disease

Objective: To explore the effect of simvastatin on the advanced aged patients with coronary heart disease.Method: 93 cases of advanced aged patients with coronary heart disease were randomly divided into the group with amount of reinforcement(n = 46) and the group with amount of routine(n = 47).The group with amount of reinforcement were given simvastatin with the dose of 40mg / d,and the group with amount of routine were given simvastatin with the dose of 20mg / d.And then examined the blood of two groups and observed the adverse response.Result: After 8 weeks,The level of TC,TG and LDL-C in two groups were reduced(P0.01),The level of HDL-C in the two groups were improved significantly(P0.01).The rate up to the standard of the group with amount of reinforcement was 71.74%(33 /46),which was higher than that of the group with amount of routine,with the rate up to the standard of 42.55%(20 /47)(X 2 = 8.08,P0.01).The rate of the adverse response between two groups has no difference(X 2 = 0.11,P 0.05).Conclusion: The effect of simvastatin with 40mg / d on the advanced aged patients with coronary heart disease is effective and safe.