Prediction Indexes of Hepatitis B Virus Intrauterine Infection

【Objective】 To investigate the value of HBV-M and HBV DNA of newborns born to HBsAg-positive mother,which were tested before combined immunization of hepatitis B.【Method】 A total of 420 infants born to HBsAg-positive mothers delivered in Obstetric Department of the Third Affiliated Hospital of Sun Yat-Sen University from June 2006 to February 2008 were followed up at least 6 months and rechecked HBV-M to confirm the diagnosis of HBV intrauterine infection,which included 33 HBsAg or HBV DNA positive newborn babies and 6 newborns with both HBsAg seropositive and HBV DNA seropositive.【Result】 HBV intrauterine infection rate was 0.95% .Using newborn both HBsAg positive and HBV DNA positive as diagnostic criterion to diagnose HBV intrauterine infection,the positive likelihood ratio was 208.3,while using newborn HBsAg positive or HBV DNA positive as diagnostic criterion,it was 14.3.【Conclusion】 Newborn both HBsAg positive and HBV DNA positive obtained before combined immunization of hepatitis B may predict HBV intrauterine infection,and it may play as a clinical index of preliminary diagnosis of HBV intrauterine infection.