2007•Inner Mongolia Medical JournalRequires access
The Expression of MMP-2 and VEGF in Endometrial Carcinoma
Guo Mei-jun
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Abstract
Objective:To study the expression of MMP-2 and VEGF in endometrial carcinoma and their relation to angiogenesis of the tumor.Methods:A total of 105 specimens including 49 cases of endometrial carcmoma,26 cases of atypical hyperplasia and 30 cases of normal endometrium were investigated by S-P immunohistochemical staining.Results:The positive rates of MMP-2 and VEGFhas all increasing trend in normal endometrium,atypical hyperplasia and endometrial carcinoma.Compared with the expression of MMP-2 and VEGF in normal endometrium,there was an significant difference in their expression m endometrial carcinoma(P0.01 andP0.05,respectively).In the grope of endometrial carcinoma,the expression of MMP-2 has a significant difference in Grade I,GradeII and Grade Ⅲcarcinoma cells(0.01P0.05);The expression of MMP-2 in different depth of myometrialinvasion has a significant difference(P0.005);MMP-2 did not show significant difference in histologictypes and tumor's FIGO stage(stage I and stage Ⅱ)(P0.05).No correlation was found between the expression of VEOF and other clinicopathological factors in endometrial carcinoma(P0.05).Conclusion:The high expression of MMP-2 and VEGF in endometrial carcinoma indicates that they play an important role in the endometrial carcinogenesis.