The expression of MMP-2 and VEGF in non-small cell lung carcinoma and their association with the prognosis.

Objective:To evaluate the expression of VEGF and MMP-2 in non-small cell lung cancer and their interaction,and to explore their association with the prognosis of NSCLC.Methods:Immunohistochemistry was used to detect the expression of VEGF and MMP-2 in pathological tissue sections of 61 cases of NSCLC.The relationship between the expression of VEGF and MMP-2 in 61 NSCLC sections and the age, sex,smoke,size of tumor,histopathological type,differentiation,stage,lymph node metastasis and survival time were analyzed statistically.Results:The expression rates of VEGF and MMP-2 in the 61 NSCLC tissue sections were 62.30% and 50.82%,respectively.The expression of VEGF and MMP-2 showed:(1)There was no significant difference among age,sex,histopathological type,tumor size and smoking level;(2)The expression rates of VEGF was associated with PTNM stage and lympha node metastasis(P0.05);the expression rates of MMP-2 was associated with lympha node metastasis and the degree of histological differentiation (P0.05);(3) There was correlation between VEGF and MMP-2 expression in NSCLC(P0.05);(4) There were significant differences of survival time between positive and negative expression groups.Conclusions:Both VEGF and MMP-2 contribute to the development,invasion and metastasis of NSCLC.They are indexes to know the biological behavior of and judge the prognosis of NSCLC.