Comparison of Anesthesia with Infusion of Remifentanil-P ropofol versus Isoflurane

Objective To evaluate the clinical profile of Remifentanil combined propofol for total intravenous anesthesia. Methods 50 ASA I～II patients ,aged 60,undergoing selective endoscopic ethmoidotomy were randomly divided into two groups of 25 patients: group C (Intravenous Anesthesia Combined Inhalation )and group R (Remifentanil-Propofol).The following were recorded and compared among these two groups:(1)the changes in MAP and HR during induction and tracheal intubation;(2)Recovery of spontaneous breathing and orientation after termination of anesthesia;(3)the time of eye opening and tracheal extubation;(4)the duration of stay in PACV;(5)OAAS scores after operation. Results (1)The MAP and HR after induction were lower than that before induction in both groups(P0.05);During intubation, no significant changes in the MAP and HR and no intubation response with group R patients were observed, while the MAP and HR in group C were higher than the basic level (P0.05) with high incidence of intubation response.(2)The recovery of sponta- neous breathing ,orientation, eye opening and stay in PACU with group R were shorter than those with group C(P0.01). The OAAS ,MMSE score and discharge from the operation room were higher in group R than in group C. The group R patients were quieter during extubation. Conclusion Induction of anesthesia with Remifentanil- Propofol is hemodynamically stabler. Recovery from anesthesia with Remifentanil-Propofol is faster than that from inhalation anesthesia, with less environment pollution in the operation room. But postoperative analgesia should be started earlier.