Clinic comparison of anesthesia of target-controlled with infusion of between propofol-remifentanil and propofol-fentanil

[Objective] To evaluate the induction of and recovery from anesthesia with target-controlled infusion (TCI) of propofol-remifentanil. [Methods] Fourty ASA I~II patients 40 undergoing elective laparoscopic cholecystectomy were randomly divided into two groups of 20 patients: group R and F. In group R anesthesia was induced and maintained with TCI propofol-remifentanil. In group F anesthesia was induced and maintained with TCI propofol-fentanyl. MAP, DBP, SBP, HR, ECG, SpO2 and PetCO2 were monitored during anesthesia. The following were recorded and compared between the 2 groups: the changes in MAP and HR during induction and tracheal incubation; recovery of spontaneous breathing and orientation after termination of anesthesia; the duration of stay in PACU; OAAS scores after operation; postoperative cognitive outcome, pain and complications like nausea and vomiting; awareness during operation. [Results] The incidence of intubation response was higher in group F than that in group R (P 0.05). The duration from termination of anesthetics to full recovery of spontaneous breathing, eye opening at request and tracheal extubation were similar between the two groups. VRS score after operation was significantly higher in group R than that in group F. The incidence of postoperative nausea and vomiting was similar between the two groups. [Conclusion] Induction of anesthesia with TCI of propofol-remifentanil is hemodynamically more stabler. However, recovery from anesthesia of TCI propofol-fentanil is better than that with TCI propofol-remifentanil. Postoperotive analgesia should be gived in group R in time.