2003•Journal of Dental Prevention and TreatmentRequires access
p16 and p53 Gene Expression in Oral Squamous Cell Carcinomas
Pan Jingsong
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Abstract
Objective To detect the clinicopathological significance of p16 and p53 gene expression in oral squamous cell carcinomas. Methods The expression of P16 and P53 were examined in 31 cases of squamous cell carcinomas with immunohistochemical techniques. Results The positive staining of P16 appeared in cell nuclei and cytoplasmas, while P53 appeared only in cell nuclei. The positive rate of P16 expression was 54.8%(13/17). 16 of 31(51.6%) samples expressed P53 protein, among which, squamous cell carcinoma grade Ⅰ was 45.5%(10/12), grade Ⅱ 33.3%(1/3), grade Ⅲ～Ⅳ 83.3%(5/6), and there was a significant difference between grade Ⅰ and grade Ⅲ～Ⅳ. Conclusion There was no correlation between the expression of p16 and p53 genes, so further studies examining mechanisms of p16 in activation are needed to clarify the relationship between p16 and p53 in oral squamous cell carcinoma.