ScholarLens Back to search
2008•Lishizhen Medicine and Materia Medica ResearchRequires access

Effects of HG Granule on Collagen Fibrosis and Hyb in the Liver of HF Model Rats Induced by Carbon Tetrar-chloride Compounded with Other Factors

Chun-Yao Wang

Open publisher page 0 citations

Abstract

Objective To explore the effects of HG Granule on collagen and Hyp in the liver of HF model rats.Methods Seventy SD rats excluding ten rats in blank control group were injected carbon tetrar-chloride(CCl4) hypodermicly,at the same,fed with the high fat and 20% ethyl alcohol for six weeks to established HF model rats.Existing rats were divided into five groups randomly acconding to sex and weight.All rats were given drugs or distilled water.Blank control group: distilled water 0.1ml/kg;model control group: distilled water 0.1 ml/kg;HG granule to high,middle,low groups:6,3,1.5 g crude drug/kg;FFgBJRGP group:1 g/kg.Through tube feeding once a day for four weeks.The contents of collagen and Hyp in the liver were assayed.Results Contents of collagen and Hyp in the model rats were significantly higher than that in blank group.After treatment of HG granule with high,middle,low dosages,collagen fibrosis and Hyp in rats decreased respectivly,FFBJRGP also decreased collagen fibrosis and Hyp in the liver.Conclusion HG granule has therapeutic action on HF model rats induced by carbon tetrar-chloride compounded with other factors.

About this research paper

What this paper is about

Objective To explore the effects of HG Granule on collagen and Hyp in the liver of HF model rats.Methods Seventy SD rats excluding ten rats in blank control group were injected carbon tetrar-chloride(CCl4) hypodermicly,at the same,fed with the high fat and 20% ethyl alcohol for six weeks to established HF model rats.Existing rats were divided into five groups randomly acconding to sex and weight.All rats were given drugs or distilled water.Blank control group: distilled water 0.1ml/kg;model control group: distilled water 0.1 ml/kg;HG granule to high,middle,low groups:6,3,1.5 g crude drug/kg;FFgBJRGP group:1 g/kg.Through tube feeding once a day for four weeks.The contents of collagen and Hyp in the liver were assayed.Results Contents of collagen and Hyp in the model rats were significantly higher than that in blank group.After treatment of HG granule with high,middle,low dosages,collagen fibrosis and Hyp in rats decreased respectivly,FFBJRGP also decreased collagen fibrosis and Hyp in the liver.Conclusion HG granule has therapeutic action on HF model rats induced by carbon tetrar-chloride compounded with other factors.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To explore the effects of HG Granule on collagen and Hyp in the liver of HF model rats.Methods Seventy SD rats excluding ten rats in blank control group were injected carbon tetrar-chloride(CCl4) hypodermicly,at the same,fed with the high fat and 20% ethyl alcohol for six weeks to established HF model rats.Existing rats were divided into five groups randomly acconding to sex and weight.All rats were given drugs or distilled water.Blank control group: distilled water 0.1ml/kg;model control group: distilled water 0.1 ml/kg;HG granule to high,middle,low groups:6,3,1.5 g crude drug/kg;FFgBJRGP group:1 g/kg.Through tube feeding once a day for four weeks.The contents of collagen and Hyp in the liver were assayed.Results Contents of collagen and Hyp in the model rats were significantly higher than that in blank group.After treatment of HG granule with high,middle,low dosages,collagen fibrosis and Hyp in rats decreased respectivly,FFBJRGP also decreased collagen fibrosis and Hyp in the liver.Conclusion HG granule has therapeutic action on HF model rats induced by carbon tetrar-chloride compounded with other factors.

Key concepts: Granule (geology), Distilled water, Chemistry, Dose, Carbon tetrachloride, CCL4, Rat model, Fibrosis

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effects of HG Granule on Collagen Fibrosis and Hyb in the Liver of HF Model Rats Induced by Carbon Tetrar-chloride Compounded with Other Factors — Research Paper | ScholarLens