The Relationship Between Angiotensin IItype 1 Receptor Gene A1166C Polymorphism and Essential Hypertension

Objective To collect the cases and compare the data of essential hypertension,study the relation between the AT1R gene A1166C polymorphism and hypertension of Chinese people. find the reason of the formation of hypertension from the molecule level and give theory support to diagnosis, treatruent and research of hypertension. To investigate the relation between AT1R gene A1166C polymorphism and essential hypertension. MethodsAT1R genotype was tested with technique of PCR-RFLP in 83 subjects with hypertension and 64 healthy subjects, the difference of gene distribution in EH group is compared with that in control group. The relation between AT1R gene A1166C polymorphism and essential hypertension was analyzed. ResultsThe frequency of AT1R genotype AA,AC and CC is 57.8%,38.6% and 3.6% respectively, compared with 67.2%,29.7% and 2.79% in normal group, there is no statistical difference (P0.05).ConclusionHypertension is an inherited disease caused by the effect of gene-gene and gene-environment. AT1R is a gene receptor subtype of the members in RAS. A1166C polymorphism locates in 3’ untranslated region of AT1R. The frequency of c allele in hypertension is higher than that in normal group, but there is no statistical significance. The relation between AT1R gene A1166C polymorphism and hypertension can’t be confirmed.