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2003•South China Journal of Cardiovascular DiseasesRequires access

The relationship between angiotensin II type 1 receptor gene A1166C polymorphism and essential hypertension

Zhou Da-xi

Open publisher page 3 citations

Abstract

Objectives To study the association of the angiotensin Ⅱ type 1 receptor gene A1166C polymorphism with essential hypertension. Methods AT 1R genotype was detected by polymerase chain reaction Restriction fagment length polymorphism in 65 hypertension and 78 healthy subjects. The difference of gene frequence in patients with hypertension was compared to that in healthy subjects. Results The frequency of AT 1R genotype AA?AC?CC were 58 6%,37 9%,3 5% in patients with hypertension group respectively, compared with 62 8%,34 1%,3 1% in normal group. There was no statistical diffe rence ( P 0 05). Conclusions Whether the AT 1R gene A1166C polymorphism is involved to essential hypertension can not be confirmed.

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What this paper is about

Objectives To study the association of the angiotensin Ⅱ type 1 receptor gene A1166C polymorphism with essential hypertension. Methods AT 1R genotype was detected by polymerase chain reaction Restriction fagment length polymorphism in 65 hypertension and 78 healthy subjects. The difference of gene frequence in patients with hypertension was compared to that in healthy subjects. Results The frequency of AT 1R genotype AA?AC?CC were 58 6%,37 9%,3 5% in patients with hypertension group respectively, compared with 62 8%,34 1%,3 1% in normal group. There was no statistical diffe rence ( P 0 05). Conclusions Whether the AT 1R gene A1166C polymorphism is involved to essential hypertension can not be confirmed.

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Available abstract

Objectives To study the association of the angiotensin Ⅱ type 1 receptor gene A1166C polymorphism with essential hypertension. Methods AT 1R genotype was detected by polymerase chain reaction Restriction fagment length polymorphism in 65 hypertension and 78 healthy subjects. The difference of gene frequence in patients with hypertension was compared to that in healthy subjects. Results The frequency of AT 1R genotype AA?AC?CC were 58 6%,37 9%,3 5% in patients with hypertension group respectively, compared with 62 8%,34 1%,3 1% in normal group. There was no statistical diffe rence ( P 0 05). Conclusions Whether the AT 1R gene A1166C polymorphism is involved to essential hypertension can not be confirmed.

Key concepts: Medicine, Essential hypertension, Genotype, Angiotensin II, Internal medicine, Gene, Gene polymorphism, Polymerase chain reaction

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