Preparation of the Angelica sinensis polysaccharide-iron complex floating sustained-release tablets and evaluation of its pharmacokinetics in dogs

OBJECTIVE To prepare Angelica sinensis polysaccharide-iron complex floating sustained-release tablets(APIC FSRT) and to evaluate its cumulative release ratio,floating properties in vitro and pharmacokinetics in Beagle dogs.METHODS The tablets were prepared using acrylic resinⅡ,HPMC,PVP and so on as excipients.And the tablet was prepared by direct compression.The floating properties in artificial gastric juice and the dissolution of the tablets in 0.1 mol·L-1 HCL solution was measured.The serum drug concentration in Beagle dogs was measured by AAS.The parameters of control groups and APIC groups in Beagle dogs were evaluated and analyzed statistically by DAS 2.0 software.RESULTS The releasing rate of the tablets was conformed to Higuchi equation.The pharmacokinetic parameters of APIC in dogs showed that the AUC(0-t)= 6.0±1.0,MRT=7.4±0.5,Cmax=1.026±0.332,the relative bioavailability of the tablets was 134%.CONCLUSION The study was found to be effective in the process of Angelica sinensis polysaccharide-iron complex floating sustained-release tablets.The cumulative release ratio was eligible,and the tablets produced a relatively flat serum drug concentration in vivo compared with the control groups.