Bioavailability study of ciprofloxacin hydrochloride intra-gastric floating sustained release tablets in dogs

OBJECTIVE To study the pharmacokinetics and bioavailability of ciprofloxacin hydrochloride intra-gastric floating sustained release tablets and its conventional tablets in six male dogs.METHODS The concentrations of ciprofloxacin hydrochloride in plasma were determined by HPLC method.The main pharmacokinetic parameters of relative bioavailability of the sustained release capsules were obtained using 3P87 program.RESULTS The Cmax of the two preparations were(3.7±0.7)mg·L-1 and(2.5±0.8)mg·L-1respectively;tmax were(1.8±0.8)h and(3.7±0.5)h and MRT were(5.7±0.5)h,(7.5±0.7)h respectively.AUC0→24 were(20.5±3.7)mg·h·L-1 and(21.4±4.7)mg·h·L-1,The relative bioavailability of the sustained-release tablets was 104.2%.CONCLUSION By the statistical analysis,the ciprofloxacin hydrochloride intra-gastric floating sustained release tablets have good sustained release characteristics and were bioequivalent to the reference formulation.