ScholarLens Back to search
2008•China Practical MedicineRequires access

Effect of alendronate sodium and simvastatin on osteoblasts cultured in vitro

Xinchen Wei

Open publisher page 0 citations

Abstract

Objective To study the effect of alendronate sodium and simvastatin on osteoblasts cultured in vitro.Methods Three weeks old SD rats osteoblasts were isolated,osteoblasts were stimulated with alendronate and simvastatin,proliferation ratio and alkaline phosphatase(ALP)activity were assessed.Results Alendronate sodium and simvastatin not only promoted proliferation of osteoblasts,but also stimulated ALP activity,combination of both drugs had a significant effect.Conclusion Alendronate sodium and simvastatin can promote proliferation and ALP activity of osteoblasts,which could be combinated to promote the form of bone.

About this research paper

What this paper is about

Objective To study the effect of alendronate sodium and simvastatin on osteoblasts cultured in vitro.Methods Three weeks old SD rats osteoblasts were isolated,osteoblasts were stimulated with alendronate and simvastatin,proliferation ratio and alkaline phosphatase(ALP)activity were assessed.Results Alendronate sodium and simvastatin not only promoted proliferation of osteoblasts,but also stimulated ALP activity,combination of both drugs had a significant effect.Conclusion Alendronate sodium and simvastatin can promote proliferation and ALP activity of osteoblasts,which could be combinated to promote the form of bone.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To study the effect of alendronate sodium and simvastatin on osteoblasts cultured in vitro.Methods Three weeks old SD rats osteoblasts were isolated,osteoblasts were stimulated with alendronate and simvastatin,proliferation ratio and alkaline phosphatase(ALP)activity were assessed.Results Alendronate sodium and simvastatin not only promoted proliferation of osteoblasts,but also stimulated ALP activity,combination of both drugs had a significant effect.Conclusion Alendronate sodium and simvastatin can promote proliferation and ALP activity of osteoblasts,which could be combinated to promote the form of bone.

Key concepts: Simvastatin, Medicine, Alkaline phosphatase, In vitro, Osteoblast, Sodium, Pharmacology, Internal medicine

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effect of alendronate sodium and simvastatin on osteoblasts cultured in vitro — Research Paper | ScholarLens