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Changes of Serum IL-18 Level in Patients of Chronic Obstructive Pulmonary Disease with Acute Exacerbation before and after the Treatment,and Its Significance

Zhou Yingna

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Abstract

Objective:To investigate the changes and significance of serum IL-18 level in patients of chronic obstructive pulmonary disease(COPD)with acute exacerbation before and after the treatment.Methods:The serum IL-18 levels of 45 COPD patients with acute exacerbation and 15 healthy people(control)were determined by using double-antibody sandwich enzyme-linked immunosorbent assay.Results:The serum IL-18 levels of COPD group before the treatment were significantly higher than those after the treatment,and both were higher than those of control group.Conclusions:IL-18 contributes to the development of COPD and its continuous high level may be one of the important factors resulting in chronic airway inflammation.

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What this paper is about

Objective:To investigate the changes and significance of serum IL-18 level in patients of chronic obstructive pulmonary disease(COPD)with acute exacerbation before and after the treatment.Methods:The serum IL-18 levels of 45 COPD patients with acute exacerbation and 15 healthy people(control)were determined by using double-antibody sandwich enzyme-linked immunosorbent assay.Results:The serum IL-18 levels of COPD group before the treatment were significantly higher than those after the treatment,and both were higher than those of control group.Conclusions:IL-18 contributes to the development of COPD and its continuous high level may be one of the important factors resulting in chronic airway inflammation.

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Available abstract

Objective:To investigate the changes and significance of serum IL-18 level in patients of chronic obstructive pulmonary disease(COPD)with acute exacerbation before and after the treatment.Methods:The serum IL-18 levels of 45 COPD patients with acute exacerbation and 15 healthy people(control)were determined by using double-antibody sandwich enzyme-linked immunosorbent assay.Results:The serum IL-18 levels of COPD group before the treatment were significantly higher than those after the treatment,and both were higher than those of control group.Conclusions:IL-18 contributes to the development of COPD and its continuous high level may be one of the important factors resulting in chronic airway inflammation.

Key concepts: Exacerbation, Medicine, COPD, Pulmonary disease, Internal medicine, Inflammation, Gastroenterology, Immunology

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Changes of Serum IL-18 Level in Patients of Chronic Obstructive Pulmonary Disease with Acute Exacerbation before and after the Treatment,and Its Significance — Research Paper | ScholarLens