Effects of parecoxib sodium on the patients with agitation during emergence from general anesthesia after laparoscopic cholecystectomy

Objective To estimate the effects of parecoxib sodium on the patients with agitation during emergence from general anesthesia after laparoscopic cholecystectomy(LC).Methods Eighty patients with ASA I～Ⅱ underwent general anesthesia for LC were randomly assigned to two groups: control group,prior to induction of anesthesia,normal saline solution 5 ml were intravenously injected;observation group,parecoxib sodium 40 mg were administered intravenously before induction of anesthesia.Two groups were compared on awaked time,extubation time,heart rate(HR),mean arterial pressure(MAP),pulse oxygen saturation(SPO2),incidence of agitation during emergence from general anesthesia,and incidence of nausea,vomiting,and respiratory depression within 24 hours postoperatively.Results There were no significant differences between two groups on the awake time and the extubation time during emergence from general anesthesia(P0.05),on the SPO2 of each record time there was no statistical differences between two groups(P0.05).However,on the HR,MAP and the incidence of agitation,in the observation group were significantly lower than in the control group(P0.05),and no respiratory depression was found in the observation group,there were also no statistical differences between two groups on the incidence of nausea and vomiting within postoperative 24 hours(P0.05).Conclusion The major finding of this study is that,preoperative intravenous administration of parecoxib sodium 40 mg can significantly reduce the incidence of agitation during emergence from general anesthesia in those patients after LC.