Clinical effect of non-small cell lung cancer treated by combined chemotherapy with Zhongliuan Capsule

AIM: To observe the clinical efficiency and side effects of non-small cell lung cancer treated by combined Zhongliuan Capsule and chemotherapy. METHODS: Randomism,double-blindness and comparison has been adopted during the test.Four hundred and thirty two lung cancer patients were randomly divided into two groups,the treatment group(Group A,324 patients) and the control group(Group B,108 patients).Patients in group A were treated with combined chemotherapy with Zhongliuan Capsule.Patients in group B were treated with combined chemotherapy with placebo.Zhongliuan Capsules or placebos were given 6 pills,three times a day,21 days as one cycle.After 2 cycles of treatment,chemotherapy passed rate,toxicity,living quality,body weight,symptoms of TCM,the size of tumor, side effects,were analysed. RESULTS: The incidence rate of adverse reactions of group A was lower than that of the group B after 1 or 2 cycles of treatment(P0.05 or P0.001).The incidence rate of adverse reactions of group A after 2 cycles of treatment was lower than that of 1 cycles treatment,but group B was higher(P0.01).The effective rate of the living quality,clinical symptoms,symptoms of TCM and body weight of group A were higher than those of group B(P0.05或P0.001).However,there was no significant difference between two groups of the chemotherapy passed rate,the size of tumor,vital signs,electrocardiogram,blood routine test,urine routine test,stool routine test,liver function test,renal routine test,bleeding and coagulation function(P0.05).All adverse events of two groups were not related to the drugs. CONCLUSION: It is safe and effective to treat non-small cell lung cancer with QI-deficiency mingled with sputum and blood coagulation symptom combined chemotherapy with Zhongliuan Capsule.