Study on patients with abnormal lipometabolism using simvastatin by two kinds of serum lipid adjusting methods

Objective To observe serum lipid level changes, cardiovascular disease events and drug adverse reactions after maintaining treatment with simvastatin and stopping treatment with simvastatin. Method To treat patients with hyperlipemia with simvastatin, some patients continue to be treated with low dosage,some patients choose to stop taking simvastatin, two groups of serum lipid levels, ischemic cardiovascular events and drug adverse reactions are separately observed after serum lipid level is normal for two,four and six months. Results Maintaining treatment with low dosage of simvastatin can effectively reduce serum total cholesterol (TCH),low-density lipoprotein cholesterol (LDL-C) and keep triglyceride(TG) in a normal range, high-density lipoprotein cholesterol (HDL-C) further rises as treatment time is prolonged. After treatment with simvastatin for half a year, it still has function to prevent cardiovascular disease. No adverse reactions is found with simvastatin after treatment with low dosage of simvastatin. Serum lipid level rebounces after stopping treatment with simvastatin. Conclusions Patients have a good tolerance, good effects and can keep continuous qualified serum lipid level after maintaining treatment with low dosage of simvastatin.