2014•Medical RecapitulateRequires access
The Application Value of Ultra Low-dose Mifepristone and Misoprostol to Terminate the Early Pregnancy
Zhang Xiao-bi
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Abstract
Objective To analyze the value of low-dose mifepristone and misoprostol to terminate the early pregnancy,and to explore its clinical applicability. Methods A total of 252 cases of pregnant women in early pregnancy were selected from China Aviation Industrial Xi'an Hospital during Jun. 2010 and Jun.2012. Using the method of random-number table,they were divided into ultra low-dose of mifepristone and misoprostol group of 132 cases and conventional-dose of mifepristone and misoprostol group of 120 cases. The successful cases of pregnancy termination,vaginal bleeding time and the distribution and adverse effects in the two groups were observed. Results Both groups of patients received effective treatment,and the success rate of the ultra low-dose of mifepristone and misoprostol group was 96. 21%( 127 cases),while it was96. 67%( 116 cases) of the conventional-dose of mifepristone and misoprostol group,the difference was not statistically significant( P 0. 05); vaginal bleeding time in the ultra low-dose of mifepristone and misoprostol group was shorter than the conventional-dose of mifepristone and misoprostol group [( 5. 1 ± 1. 5) d vs( 6.1 ±1.5) d]( P 0.05),the rate of bleeding stop within 7 days in the ultra low-dose of mifepristone and misoprostol group was 95. 45%( 126 cases),while in the conventional-dose of mifepristone and misoprostol group was 93. 33%( 112 cases),the difference was not statistically significant( P 0. 05); the incidence of adverse effects of the ultra low-dose of mifepristone and misoprostol group was 18. 18%( 24 cases),while it was 30. 00%( 36 cases) in the conventional-dose of mifepristone and misoprostol group,the difference was statistically significant( P 0. 05). Conclusion Ultra low doses of mifepristone and misoprostol to terminate early pregnancy is effective,while the adverse effects are significantly less than the conventional dose therapy,and is suitable for long-term clinical application.