The mechanisms of inhibition in proliferation of the human gastric cancer cell line BGC823 cells by resveratrol

Objective To explore the mechanisms of resveratrol which inhibiti proliferation of the human gastric carcinoma cell line BGC823 cells. Methods By MTT assay and flow cytometry (FCM) were respectively used to determine the influence of resveratrol which affected the gastric carcinoma cell line BGC823 cells in its proliferation and cell cycle for 48 hours. Results The inhibitive rates of gastric carcinoma cell line BGC823 were 19.1%, 25.3%, 52.6%, 67.9% and 91.3% with 1.5,3.0,6.0,12.0,24.0 mg/L concentration of resveratrol respectively. The clone formation of BGC823 cell was evidently inhibited and cell cycle was arrested in S-phase and inhibited telomerase activity after it was treated with resveratrol. Conclusion The effect of resveratrol which inhibited the proliferation of the human gastric carcinoma cell line BGC823 was related with S-phase arresting of cell cycle.