Changes and evaluation of hs-CRP and sVCAM-1 in patients with acute coronary syndrome

Objective To investigate the relation of inflammation markers to acute coronary syndrome(ACS)and their clinical significance by observing the changes of hs-CRP and VCAM-1 in patients with unstable agina pectoris(UAP) and acute myocardial infarction(AMI).Methods The concentrations of serum hs-CRP and sVCAM-1 were assayed by enzyme linked immunosorbant assay,the severity of coronary atherosclerosis was evaluated by coronary angiography and recorded in 50 patients with ACS and 30 controls.Results The concentrations of serum hs-CRP and sVCAM-1 were significantly higher in ACS patients than those in controls(P0.01),and significantly higher in AMI patients than those in UAP patients(P0.01).There was significant positive correlation between the concentration of serum sVCAM-1 and the lesion extent of involved coronary artery(r=0.450 P0.01).Conlusions Serum hs-CRP and sVCAM-1 levels are closely correlated with the development of ACS,and the concentrations of serum sVCAM-1 reflect the lesion extent of coronary artery.