Changes and evaluation of inflammation markers in acute coronary syndrome

AIM To investigate the relation of inflammation markers to acute coronary syndrome(ACS)and the clinical significance.METHODS The concentrations of serum sVCAM-1 and vWF were assayed by ELISA and the severity of coronary atherosclerosis was evaluated by coronary angiography in 22 patients with acute myocardial infarction(AMI),37 patients with unstable agina pectoris and 30 controls.RESULTS The concentrations of serum sVCAM-1 were significantly higher in ACS patients than those in controls(P0.01) and significantly higher in AMI patients than those in UAP patients.The concentrations of serum vWF were significantly higher in ACS patients than those in controls(P0.01),but there was no significant difference between the AMI and UAP patients.There was a significant positive correlation between the concentration of serum sVCAM-1 and the lesion extension of coronary artery(r=0.450 P0.01).CONCLUSION Serum sVCAM-1 levels are correlated with the lesion extension of coronary artery and vWF is a factor in the generation and development of ACS.