EFFECTS OFPAEONOLON VENTRICULAR REMODELINGAND CARDIAC FUNCTION OFACUTE MYOCARDIALINFARCTION RATS

Objective:To observe the effects of paeonol on ventricular remodeling and cardiac function of acute myocardial infarction(AMI) rats’ model.Methods:Male Wistar rats were randomly divided into sham-operation group,model group,paeonol low dose group(4mg/kg/d),paeonol high dose group(8mg/kg/d) and captopril control group(10mg/ kg/d).The AMI rats’ model was established by ligating the anterior descending branch of left coronary artery.After the AMI rats’ model was successfully established,the rats in each drug group were respectively lavaged with corresponding drugs for 4 weeks.The hemodynamic parameters of rats in each group were respectively detected;HE stain was used to observe the pathological changes of myocardium.Results: High dose paeonol and captopril could obviously increase the left ventricular systolic pressure(LVSP),left ventricular pressure maximum rise and fall rate(±dp/dtmax) of model rats,decrease the left ventricular end diastolic pressure(LVEDP);High dose paeonol and captopril also could obviously improve the pathological changes of myocardium of model rats.Conclusions: Paeonol can improve ventricular remodeling and cardiac function of AMI rats’model in a certain extent.