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2009•Journal of Ningxia Medical UniversityRequires access

An Analysis of Immunophenotype with Three-color Flow Cytometry in Patients with Acute Promyelocytic Leukemia

Wang Gui-jie

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Abstract

Objective To explore the immunophenoytpe of acute promyelocytic leukemia.Methods Immunophenotype was examined by three-color flow cytometry in bone marrow of 31 patients with AML-M3 of FAB.Results CD13 and CD33 were expressed in all 33 patients(100%).CD34 and HLA-DR were expressed in 2 of 33(3.0%) and CD117 were expressed in 21 of 33(63.6%).Conclusion CD45/SSC door in three-color flow cytometry can classify effectively naive cells from normal cells and specifically analyze he naive cell.This method can improve diagnositic accuracy of immunophenoytpe in acute promyelocytic leukemia.

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What this paper is about

Objective To explore the immunophenoytpe of acute promyelocytic leukemia.Methods Immunophenotype was examined by three-color flow cytometry in bone marrow of 31 patients with AML-M3 of FAB.Results CD13 and CD33 were expressed in all 33 patients(100%).CD34 and HLA-DR were expressed in 2 of 33(3.0%) and CD117 were expressed in 21 of 33(63.6%).Conclusion CD45/SSC door in three-color flow cytometry can classify effectively naive cells from normal cells and specifically analyze he naive cell.This method can improve diagnositic accuracy of immunophenoytpe in acute promyelocytic leukemia.

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Available abstract

Objective To explore the immunophenoytpe of acute promyelocytic leukemia.Methods Immunophenotype was examined by three-color flow cytometry in bone marrow of 31 patients with AML-M3 of FAB.Results CD13 and CD33 were expressed in all 33 patients(100%).CD34 and HLA-DR were expressed in 2 of 33(3.0%) and CD117 were expressed in 21 of 33(63.6%).Conclusion CD45/SSC door in three-color flow cytometry can classify effectively naive cells from normal cells and specifically analyze he naive cell.This method can improve diagnositic accuracy of immunophenoytpe in acute promyelocytic leukemia.

Key concepts: Immunophenotyping, Acute promyelocytic leukemia, CD117, Flow cytometry, CD34, Medicine, Leukemia, CD33

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