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2007•Acta Academiae Medicinae Qingdao UniversitatisRequires access

OBSERVATION ON CLINICAL EFFECTS OF CEFEPIME IN THE TREATMENT OF HOSPITAL-ACQUIRED PNEUMONIA

Lu Ren

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Abstract

Objective To assess the therapeutic effects of cefepime in treating hospital-acquired pneumonia. Methods Seventy-one patients were randomly divided into two groups.The patients in treated group(n=36) were given cefepime 2 g,iv drip,q12 h,and ceftazidime 2 g,iv drip,q12 h,in the control group(n=35),the course being 7-14 d for both groups. Results In the cefepime group,the cure rate,response rate,the bacterial eradication rate were 69.4%,86.1%,and 85.3%,respectively,while in the ceftazidime group,they were 68.6%,82.9%,and 83.3%.There was no statistically significant difference between the two groups.The susceptibility rates of clinical isolates to cefepime were higher than those of ceftazidime(χ2=7.465,P0.01). Conclusion The antibacterial activity of cefepime is stronger than that of ceftazidime.Cefepime is effective and safe in the treatment of hospital-acquired pneumonia.

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Objective To assess the therapeutic effects of cefepime in treating hospital-acquired pneumonia. Methods Seventy-one patients were randomly divided into two groups.The patients in treated group(n=36) were given cefepime 2 g,iv drip,q12 h,and ceftazidime 2 g,iv drip,q12 h,in the control group(n=35),the course being 7-14 d for both groups. Results In the cefepime group,the cure rate,response rate,the bacterial eradication rate were 69.4%,86.1%,and 85.3%,respectively,while in the ceftazidime group,they were 68.6%,82.9%,and 83.3%.There was no statistically significant difference between the two groups.The susceptibility rates of clinical isolates to cefepime were higher than those of ceftazidime(χ2=7.465,P0.01). Conclusion The antibacterial activity of cefepime is stronger than that of ceftazidime.Cefepime is effective and safe in the treatment of hospital-acquired pneumonia.

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Available abstract

Objective To assess the therapeutic effects of cefepime in treating hospital-acquired pneumonia. Methods Seventy-one patients were randomly divided into two groups.The patients in treated group(n=36) were given cefepime 2 g,iv drip,q12 h,and ceftazidime 2 g,iv drip,q12 h,in the control group(n=35),the course being 7-14 d for both groups. Results In the cefepime group,the cure rate,response rate,the bacterial eradication rate were 69.4%,86.1%,and 85.3%,respectively,while in the ceftazidime group,they were 68.6%,82.9%,and 83.3%.There was no statistically significant difference between the two groups.The susceptibility rates of clinical isolates to cefepime were higher than those of ceftazidime(χ2=7.465,P0.01). Conclusion The antibacterial activity of cefepime is stronger than that of ceftazidime.Cefepime is effective and safe in the treatment of hospital-acquired pneumonia.

Key concepts: Cefepime, Ceftazidime, Medicine, Pneumonia, Hospital-acquired pneumonia, Internal medicine, Biology, Bacteria

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