Distribution and Resistance of Clinical Isolates in Xiangya Hospital in 2003

Objective To investigate the distribution and drug resistance profiles of clinical isolates in Xiangya hospital in 2003 and to provide guidance for the proper use of antibiotics. Method Bacteria identification and susceptibility test were performed by Microscan system and K-B disk method,and the statistical analysis was performed by SPSS software. Results Among the 3,747 clinical isolates collected in 2003 from Xiangya hospital,gram-negative bacilli(G~-)and gram-positive cocci(G~+)accounted for 54.8%(2,052/3,747) and 43.5%(1,629/3,747) respectively.The Pseudomonsa aeruginosa, Escherichia coli,Klebsiella pneumonia,Acinetobacter baumannii and Enterobacter cloacae were the most common pathogens among the gram-negative bacilli.The resistance rate of these strains to meropenem was only 0%～6.4%,which was the lowest;and followed by cefoperazone/sulbactam.The resistance rate of gram-negative bacilli to other common antibiotics was from 4.4% to 85.9%.The coagulase negative Staphylococci(CNS) accounted for 57.0%(929/1,629),which was the most common among the G~+ cocci.Among Staphylococcus aureus(SA) and CNS,resistant isolates to methicillin accounted for 55.1% and 61.7% respectively;but the vancomycin-resistant(VRE) or intermediate strains were not found.Deoxycycline was the effective antibiotics against Staphylococcus second to vancomycin.The resistance rate was(2.8%)～4.4%,and the resistance rate to erythromycin,SMZ-TMP and azithromycin was from 73.3% to 88.6%. Conclusion Staphylococcus,Enterobacteriaceae,Pseudomonsa aeruginosa, Acinetobacter baumannii and Enterococcus are the most common pathogens isolated from Xiangya hospital,and the drug resistance profiles of clinical isolates are substantial.We should strengthen resistance monitoring of clinical isolates and use antibiotic reasonably.