The expression of livin,caspase-3 and MTA1 in the colon cancer and their correlation

Objective To explore livin,MTA1 and the caspase-3 protein expression,their correlation and clinical pathology in colon cancer.Methods The expressions of livin,MTA1 and caspase-3 protein in 88 cases of colon cancer were detected by immunohistochemistry staining.Results Livin,caspase-3 protein and MTA1 positive expression rates in colon cancer tissues were more than those in tissues beside the cancer.Furthermore there were obvious relevance between livin protein,MTA1 positive expression rate and degree of histodifferentiation and lymph node metabasis and between caspase-3 protein positive expression rate and degree of histodifferentiation of colon cancer.Caspase-3 protein expression had prominent inverse correlation with the livin expression.Conclusions ①Over expression of livin having inhibtion on colon cancer is one of important factors of colon carcinogenesis.②Caspase-3 protein expression in colon cancer tissues is inhibited to less and has prominent inverse correlation with livin expression.Accordingly,suppressing caspase-3 protein activity is one of channels,by which livin promotes colon carcinogenesis.③MTA1 plays the important role in histodifferentiation degree and lymph node metastasis of colon cancer.