2014•Dalian Yike Daxue xuebaoRequires access
Expression of Livin gene in colon cancer and its relationship with PTEN and Caspase- 3
Yao Wen-jua
Open publisher page 0 citations
Abstract
Objective To explore Livin,PTEN and Caspase-3 protein expression and their correlationship in colon cancer. Methods The expressions of Livin,PTEN and Caspase- 3 protein in 50 cases of colon cancer,colon adenoma and normal colorectal mucosa were detectded by immunohistochemistry staining. Results(1)The expression of Livin in colon cancer,colon adenoma and normal colorectal mucosa was 64. 00%,56. 00%,18. 00%. Livin protein positive expression rates in colon cancer tissues was more than those in colon adenoma and nomal colorectal mucosa and had statistical significance.(2) The expression of PTEN in colon cancer,colon adenoma and normal colorectal mucosa was 40. 00%,76. 00%,98. 00%. The expression of Caspase- 3 in colon cancer,colon adenoma and normal colorectal mucosa was 46. 00%,84. 00%,92. 00%. Caspase- 3 and PTEN protein positive expression rates in colon cancer tissues were less than those in colon adenoma and nomal colorectal mucosa(P 0. 01).(3) Caspase- 3,PTEN protein expression had prominent inverse correlation with the Livin expression. Conclusion Livin,PTEN,Caspase- 3 participate the happen and the development of colon cancer. The suppressed of PTEN protein may accelerate the express of Livin,and promote the happening of colon cancer. Livin promotes colon cancer through inhibited caspase- 3 protein activity.