The effect and tolerance with co-administration of nateglinide and insulin glargine in type 2 diabetes

Objective To evaluate the effect and tolerance of co-administration of nateglinide and insulin glargine in type 2 diabetes(T2DM).Methods The fasting blood glucose(FBG),postprandial blood glucose(BG),glycosylated hemoglobin(HbA) and the undulation of blood glucose with co-administration of nateglinide and insulin glargine were evaluated in 57 T2DM greater than 60 yrars old.Results Compared to beforetreatment,BG was significantly decreased after co-administration of nateglinide and insulin glargine before breakfast,at 2 hours after lunch and supper and before retiring(P0.05),which was more at 2 hours after breakfast and before lunch(P0.01).There was a tendency of decrease in BG before supper and at 3 AM in the early morning(P0.05).Conclusion Nateglinide combined with insulin glargine can be used effectively and safely to treat T2DM patients aged greater than 60 yrars old.